diff --git a/.eslintrc.json b/.eslintrc.json
index a2de6671..3186a491 100644
--- a/.eslintrc.json
+++ b/.eslintrc.json
@@ -97,6 +97,7 @@
                 "parseUrl": "readonly",
                 "areSetsEqual": "readonly",
                 "getSetIntersection": "readonly",
+                "getSetDifference": "readonly",
                 "EventDispatcher": "readonly",
                 "EventListenerCollection": "readonly",
                 "EXTENSION_IS_BROWSER_EDGE": "readonly"
diff --git a/ext/bg/js/profile-conditions.js b/ext/bg/js/profile-conditions.js
index a0710bd1..c0f5d3f5 100644
--- a/ext/bg/js/profile-conditions.js
+++ b/ext/bg/js/profile-conditions.js
@@ -36,6 +36,24 @@ function _profileConditionTestDomainList(url, domainList) {
     return false;
 }
 
+const _profileModifierKeys = [
+    {optionValue: 'alt',   name: 'Alt'},
+    {optionValue: 'ctrl',  name: 'Ctrl'},
+    {optionValue: 'shift', name: 'Shift'}
+];
+
+if (!hasOwn(window, 'netscape')) {
+    _profileModifierKeys.push({optionValue: 'meta',  name: 'Meta'});
+}
+
+const _profileModifierValueToName = new Map(
+    _profileModifierKeys.map(({optionValue, name}) => [optionValue, name])
+);
+
+const _profileModifierNameToValue = new Map(
+    _profileModifierKeys.map(({optionValue, name}) => [name, optionValue])
+);
+
 const profileConditionsDescriptor = {
     popupLevel: {
         name: 'Popup Level',
@@ -100,5 +118,53 @@ const profileConditionsDescriptor = {
                 test: ({url}, transformedOptionValue) => (transformedOptionValue !== null && transformedOptionValue.test(url))
             }
         }
+    },
+    modifierKeys: {
+        name: 'Modifier Keys',
+        description: 'Use profile depending on the active modifier keys.',
+        values: _profileModifierKeys,
+        defaultOperator: 'are',
+        operators: {
+            are: {
+                name: 'are',
+                placeholder: 'Press one or more modifier keys here',
+                defaultValue: '',
+                type: 'keyMulti',
+                transform: (optionValue) => optionValue
+                    .split(' + ')
+                    .filter((v) => v.length > 0)
+                    .map((v) => _profileModifierNameToValue.get(v)),
+                transformReverse: (transformedOptionValue) => transformedOptionValue
+                    .map((v) => _profileModifierValueToName.get(v))
+                    .join(' + '),
+                test: ({modifierKeys}, optionValue) => areSetsEqual(new Set(modifierKeys), new Set(optionValue))
+            },
+            areNot: {
+                name: 'are not',
+                placeholder: 'Press one or more modifier keys here',
+                defaultValue: '',
+                type: 'keyMulti',
+                transform: (optionValue) => optionValue
+                    .split(' + ')
+                    .filter((v) => v.length > 0)
+                    .map((v) => _profileModifierNameToValue.get(v)),
+                transformReverse: (transformedOptionValue) => transformedOptionValue
+                    .map((v) => _profileModifierValueToName.get(v))
+                    .join(' + '),
+                test: ({modifierKeys}, optionValue) => !areSetsEqual(new Set(modifierKeys), new Set(optionValue))
+            },
+            include: {
+                name: 'include',
+                type: 'select',
+                defaultValue: 'alt',
+                test: ({modifierKeys}, optionValue) => modifierKeys.includes(optionValue)
+            },
+            notInclude: {
+                name: 'don\'t include',
+                type: 'select',
+                defaultValue: 'alt',
+                test: ({modifierKeys}, optionValue) => !modifierKeys.includes(optionValue)
+            }
+        }
     }
 };
diff --git a/ext/bg/js/search.js b/ext/bg/js/search.js
index b7d2eed8..47d495e6 100644
--- a/ext/bg/js/search.js
+++ b/ext/bg/js/search.js
@@ -17,6 +17,7 @@
 
 /* global
  * ClipboardMonitor
+ * DOM
  * Display
  * QueryParser
  * apiClipboardGet
@@ -178,7 +179,7 @@ class DisplaySearch extends Display {
     }
 
     onKeyDown(e) {
-        const key = Display.getKeyFromEvent(e);
+        const key = DOM.getKeyFromEvent(e);
         const ignoreKeys = this._onKeyDownIgnoreKeys;
 
         const activeModifierMap = new Map([
diff --git a/ext/bg/js/settings/conditions-ui.js b/ext/bg/js/settings/conditions-ui.js
index 84498b42..5b356101 100644
--- a/ext/bg/js/settings/conditions-ui.js
+++ b/ext/bg/js/settings/conditions-ui.js
@@ -16,6 +16,7 @@
  */
 
 /* global
+ * DOM
  * conditionsNormalizeOptionValue
  */
 
@@ -177,7 +178,8 @@ ConditionsUI.Condition = class Condition {
         this.parent = parent;
         this.condition = condition;
         this.container = ConditionsUI.instantiateTemplate('#condition-template').appendTo(parent.container);
-        this.input = this.container.find('input');
+        this.input = this.container.find('.condition-input');
+        this.inputInner = null;
         this.typeSelect = this.container.find('.condition-type');
         this.operatorSelect = this.container.find('.condition-operator');
         this.removeButton = this.container.find('.condition-remove');
@@ -186,14 +188,13 @@ ConditionsUI.Condition = class Condition {
         this.updateOperators();
         this.updateInput();
 
-        this.input.on('change', this.onInputChanged.bind(this));
         this.typeSelect.on('change', this.onConditionTypeChanged.bind(this));
         this.operatorSelect.on('change', this.onConditionOperatorChanged.bind(this));
         this.removeButton.on('click', this.onRemoveClicked.bind(this));
     }
 
     cleanup() {
-        this.input.off('change');
+        this.inputInner.off('change');
         this.typeSelect.off('change');
         this.operatorSelect.off('change');
         this.removeButton.off('click');
@@ -236,21 +237,48 @@ ConditionsUI.Condition = class Condition {
     updateInput() {
         const conditionDescriptors = this.parent.parent.conditionDescriptors;
         const {type, operator} = this.condition;
+
+        const objects = [];
+        let inputType = null;
+        if (hasOwn(conditionDescriptors, type)) {
+            const conditionDescriptor = conditionDescriptors[type];
+            objects.push(conditionDescriptor);
+            if (hasOwn(conditionDescriptor, 'type')) {
+                inputType = conditionDescriptor.type;
+            }
+            if (hasOwn(conditionDescriptor.operators, operator)) {
+                const operatorDescriptor = conditionDescriptor.operators[operator];
+                objects.push(operatorDescriptor);
+                if (hasOwn(operatorDescriptor, 'type')) {
+                    inputType = operatorDescriptor.type;
+                }
+            }
+        }
+
+        this.input.empty();
+        if (inputType === 'select') {
+            this.inputInner = this.createSelectElement(objects);
+        } else if (inputType === 'keyMulti') {
+            this.inputInner = this.createInputKeyMultiElement(objects);
+        } else {
+            this.inputInner = this.createInputElement(objects);
+        }
+        this.inputInner.appendTo(this.input);
+        this.inputInner.on('change', this.onInputChanged.bind(this));
+
+        const {valid} = this.validateValue(this.condition.value);
+        this.inputInner.toggleClass('is-invalid', !valid);
+        this.inputInner.val(this.condition.value);
+    }
+
+    createInputElement(objects) {
+        const inputInner = ConditionsUI.instantiateTemplate('#condition-input-text-template');
+
         const props = new Map([
             ['placeholder', ''],
             ['type', 'text']
         ]);
 
-        const objects = [];
-        if (hasOwn(conditionDescriptors, type)) {
-            const conditionDescriptor = conditionDescriptors[type];
-            objects.push(conditionDescriptor);
-            if (hasOwn(conditionDescriptor.operators, operator)) {
-                const operatorDescriptor = conditionDescriptor.operators[operator];
-                objects.push(operatorDescriptor);
-            }
-        }
-
         for (const object of objects) {
             if (hasOwn(object, 'placeholder')) {
                 props.set('placeholder', object.placeholder);
@@ -266,12 +294,95 @@ ConditionsUI.Condition = class Condition {
         }
 
         for (const [prop, value] of props.entries()) {
-            this.input.prop(prop, value);
+            inputInner.prop(prop, value);
         }
 
-        const {valid} = this.validateValue(this.condition.value);
-        this.input.toggleClass('is-invalid', !valid);
-        this.input.val(this.condition.value);
+        return inputInner;
+    }
+
+    createInputKeyMultiElement(objects) {
+        const inputInner = this.createInputElement(objects);
+
+        inputInner.prop('readonly', true);
+
+        let values = [];
+        for (const object of objects) {
+            if (hasOwn(object, 'values')) {
+                values = object.values;
+            }
+        }
+
+        const pressedKeyIndices = new Set();
+
+        const onKeyDown = ({originalEvent}) => {
+            const pressedKeyEventName = DOM.getKeyFromEvent(originalEvent);
+            if (pressedKeyEventName === 'Escape' || pressedKeyEventName === 'Backspace') {
+                pressedKeyIndices.clear();
+                inputInner.val('');
+                inputInner.change();
+                return;
+            }
+
+            const pressedModifiers = DOM.getActiveModifiers(originalEvent);
+            // https://developer.mozilla.org/en-US/docs/Web/API/KeyboardEvent/metaKey
+            // https://askubuntu.com/questions/567731/why-is-shift-alt-being-mapped-to-meta
+            // It works with mouse events on some platforms, so try to determine if metaKey is pressed
+            // hack; only works when Shift and Alt are not pressed
+            const isMetaKeyChrome = (
+                pressedKeyEventName === 'Meta' &&
+                getSetDifference(new Set(['shift', 'alt']), pressedModifiers).size !== 0
+            );
+            if (isMetaKeyChrome) {
+                pressedModifiers.add('meta');
+            }
+
+            for (const modifier of pressedModifiers) {
+                const foundIndex = values.findIndex(({optionValue}) => optionValue === modifier);
+                if (foundIndex !== -1) {
+                    pressedKeyIndices.add(foundIndex);
+                }
+            }
+
+            const inputValue = [...pressedKeyIndices].map((i) => values[i].name).join(' + ');
+            inputInner.val(inputValue);
+            inputInner.change();
+        };
+
+        inputInner.on('keydown', onKeyDown);
+
+        return inputInner;
+    }
+
+    createSelectElement(objects) {
+        const inputInner = ConditionsUI.instantiateTemplate('#condition-input-select-template');
+
+        const data = new Map([
+            ['values', []],
+            ['defaultValue', null]
+        ]);
+
+        for (const object of objects) {
+            if (hasOwn(object, 'values')) {
+                data.set('values', object.values);
+            }
+            if (hasOwn(object, 'defaultValue')) {
+                data.set('defaultValue', object.defaultValue);
+            }
+        }
+
+        for (const {optionValue, name} of data.get('values')) {
+            const option = ConditionsUI.instantiateTemplate('#condition-input-option-template');
+            option.attr('value', optionValue);
+            option.text(name);
+            option.appendTo(inputInner);
+        }
+
+        const defaultValue = data.get('defaultValue');
+        if (defaultValue !== null) {
+            inputInner.val(defaultValue);
+        }
+
+        return inputInner;
     }
 
     validateValue(value) {
@@ -291,9 +402,9 @@ ConditionsUI.Condition = class Condition {
     }
 
     onInputChanged() {
-        const {valid, value} = this.validateValue(this.input.val());
-        this.input.toggleClass('is-invalid', !valid);
-        this.input.val(value);
+        const {valid, value} = this.validateValue(this.inputInner.val());
+        this.inputInner.toggleClass('is-invalid', !valid);
+        this.inputInner.val(value);
         this.condition.value = value;
         this.save();
     }
diff --git a/ext/bg/settings.html b/ext/bg/settings.html
index a0220e96..fc9221f8 100644
--- a/ext/bg/settings.html
+++ b/ext/bg/settings.html
@@ -117,7 +117,7 @@
                     <div class="input-group-btn"><select class="form-control btn btn-default condition-type"><optgroup label="Type"></optgroup></select></div>
                     <div class="input-group-btn"><select class="form-control btn btn-default condition-operator"><optgroup label="Operator"></optgroup></select></div>
                     <div class="condition-line-break"></div>
-                    <div class="condition-input"><input type="text" class="form-control" /></div>
+                    <div class="condition-input"></div>
                     <div class="input-group-btn"><button class="btn btn-danger condition-remove" title="Remove"><span class="glyphicon glyphicon-remove"></span></button></div>
                 </div></template>
                 <template id="condition-group-separator-template"><div class="input-group">
@@ -126,6 +126,9 @@
                 <template id="condition-group-options-template"><div class="condition-group-options">
                     <button class="btn btn-default condition-add"><span class="glyphicon glyphicon-plus"></span></button>
                 </div></template>
+                <template id="condition-input-text-template"><input type="text" class="form-control condition-input-inner" /></template>
+                <template id="condition-input-select-template"><select class="form-control condition-input-inner"></select></template>
+                <template id="condition-input-option-template"><option></option></template>
             </div>
 
             <div>
diff --git a/ext/fg/js/frontend.js b/ext/fg/js/frontend.js
index 76ad27e0..d979246d 100644
--- a/ext/fg/js/frontend.js
+++ b/ext/fg/js/frontend.js
@@ -50,6 +50,9 @@ class Frontend {
         );
         this._textScanner.onSearchSource = this.onSearchSource.bind(this);
 
+        this._activeModifiers = new Set();
+        this._optionsUpdatePending = false;
+
         this._windowMessageHandlers = new Map([
             ['popupClose', () => this._textScanner.clearSelection(false)],
             ['selectionCopy', () => document.execCommand('copy')]
@@ -90,6 +93,7 @@ class Frontend {
             chrome.runtime.onMessage.addListener(this.onRuntimeMessage.bind(this));
 
             this._textScanner.on('clearSelection', this.onClearSelection.bind(this));
+            this._textScanner.on('activeModifiersChanged', this.onActiveModifiersChanged.bind(this));
 
             this._updateContentScale();
             this._broadcastRootPopupInformation();
@@ -173,12 +177,21 @@ class Frontend {
         }
     }
 
+    async updatePendingOptions() {
+        if (this._optionsUpdatePending) {
+            this._optionsUpdatePending = false;
+            await this.updateOptions();
+        }
+    }
+
     async setTextSource(textSource) {
         await this.onSearchSource(textSource, 'script');
         this._textScanner.setCurrentTextSource(textSource);
     }
 
     async onSearchSource(textSource, cause) {
+        await this.updatePendingOptions();
+
         let results = null;
 
         try {
@@ -254,12 +267,24 @@ class Frontend {
     onClearSelection({passive}) {
         this.popup.hide(!passive);
         this.popup.clearAutoPlayTimer();
+        this.updatePendingOptions();
+    }
+
+    async onActiveModifiersChanged({modifiers}) {
+        if (areSetsEqual(modifiers, this._activeModifiers)) { return; }
+        this._activeModifiers = modifiers;
+        if (await this.popup.isVisible()) {
+            this._optionsUpdatePending = true;
+            return;
+        }
+        await this.updateOptions();
     }
 
     async getOptionsContext() {
         const url = this._getUrl !== null ? await this._getUrl() : window.location.href;
         const depth = this.popup.depth;
-        return {depth, url};
+        const modifierKeys = [...this._activeModifiers];
+        return {depth, url, modifierKeys};
     }
 
     _showPopupContent(textSource, optionsContext, type=null, details=null) {
diff --git a/ext/mixed/js/core.js b/ext/mixed/js/core.js
index fbe9943a..835d9cea 100644
--- a/ext/mixed/js/core.js
+++ b/ext/mixed/js/core.js
@@ -146,6 +146,12 @@ function getSetIntersection(set1, set2) {
     return result;
 }
 
+function getSetDifference(set1, set2) {
+    return new Set(
+        [...set1].filter((value) => !set2.has(value))
+    );
+}
+
 
 /*
  * Async utilities
diff --git a/ext/mixed/js/display.js b/ext/mixed/js/display.js
index 32081c70..783af7d8 100644
--- a/ext/mixed/js/display.js
+++ b/ext/mixed/js/display.js
@@ -338,7 +338,7 @@ class Display {
     }
 
     onKeyDown(e) {
-        const key = Display.getKeyFromEvent(e);
+        const key = DOM.getKeyFromEvent(e);
         const handler = this._onKeyDownHandlers.get(key);
         if (typeof handler === 'function') {
             if (handler(e)) {
@@ -964,11 +964,6 @@ class Display {
         return elementRect.top - documentRect.top;
     }
 
-    static getKeyFromEvent(event) {
-        const key = event.key;
-        return (typeof key === 'string' ? (key.length === 1 ? key.toUpperCase() : key) : '');
-    }
-
     async _getNoteContext() {
         const documentTitle = await this.getDocumentTitle();
         return {
diff --git a/ext/mixed/js/dom.js b/ext/mixed/js/dom.js
index 31ba33d6..0e8f4462 100644
--- a/ext/mixed/js/dom.js
+++ b/ext/mixed/js/dom.js
@@ -63,6 +63,20 @@ class DOM {
         }
     }
 
+    static getActiveModifiers(event) {
+        const modifiers = new Set();
+        if (event.altKey) { modifiers.add('alt'); }
+        if (event.ctrlKey) { modifiers.add('ctrl'); }
+        if (event.metaKey) { modifiers.add('meta'); }
+        if (event.shiftKey) { modifiers.add('shift'); }
+        return modifiers;
+    }
+
+    static getKeyFromEvent(event) {
+        const key = event.key;
+        return (typeof key === 'string' ? (key.length === 1 ? key.toUpperCase() : key) : '');
+    }
+
     static getFullscreenElement() {
         return (
             document.fullscreenElement ||
diff --git a/ext/mixed/js/text-scanner.js b/ext/mixed/js/text-scanner.js
index 774eef44..d74a04f8 100644
--- a/ext/mixed/js/text-scanner.js
+++ b/ext/mixed/js/text-scanner.js
@@ -70,6 +70,9 @@ class TextScanner extends EventDispatcher {
             return;
         }
 
+        const modifiers = DOM.getActiveModifiers(e);
+        this.trigger('activeModifiersChanged', {modifiers});
+
         const scanningOptions = this.options.scanning;
         const scanningModifier = scanningOptions.modifier;
         if (!(