diff --git a/ext/css/display.css b/ext/css/display.css
index 607368fc..7953f6ef 100644
--- a/ext/css/display.css
+++ b/ext/css/display.css
@@ -1670,7 +1670,7 @@ button.footer-notification-close-button:active {
 
 
 /* Audio menu */
-.audio-button-popup-menu[data-show-icons=false] .popup-menu-item-icon {
+.audio-button-popup-menu[data-show-icons=false] .popup-menu-item-audio-button .popup-menu-item-icon {
     display: none;
 }
 .audio-button-popup-menu .popup-menu-item-icon[data-icon=checkmark] {
@@ -1682,6 +1682,42 @@ button.footer-notification-close-button:active {
 .audio-button-popup-menu .popup-menu-item-group[data-source-in-options=false][data-valid=null] .popup-menu-item {
     color: var(--text-color-light1);
 }
+.popup-menu-item-audio-button .popup-menu-item-label {
+    padding-right: 2.5em;
+}
+.popup-menu-item-set-primary-audio-button {
+    flex-flow: row nowrap;
+    align-items: center;
+    justify-content: center;
+    position: absolute;
+    right: 0;
+    top: 0;
+    bottom: 0;
+    width: 2.5em;
+}
+.popup-menu-item-set-primary-audio-button:not([hidden]) {
+    display: flex;
+}
+.popup-menu-item-set-primary-audio-button .popup-menu-item-icon {
+    opacity: 0;
+    transition: opacity var(--animation-duration) linear;
+}
+.popup-menu-item-group:hover .popup-menu-item-set-primary-audio-button .popup-menu-item-icon {
+    opacity: 0.25;
+}
+.popup-menu-item-group .popup-menu-item-set-primary-audio-button:hover .popup-menu-item-icon,
+.popup-menu-item-group .popup-menu-item-set-primary-audio-button:active .popup-menu-item-icon,
+.popup-menu-item-group .popup-menu-item-set-primary-audio-button:focus .popup-menu-item-icon {
+    opacity: 0.375;
+}
+.popup-menu-item-group[data-is-primary-card-audio=true] .popup-menu-item-set-primary-audio-button .popup-menu-item-icon {
+    opacity: 1;
+}
+.popup-menu-item-group[data-is-primary-card-audio=true] .popup-menu-item-set-primary-audio-button:hover .popup-menu-item-icon,
+.popup-menu-item-group[data-is-primary-card-audio=true] .popup-menu-item-set-primary-audio-button:active .popup-menu-item-icon,
+.popup-menu-item-group[data-is-primary-card-audio=true] .popup-menu-item-set-primary-audio-button:focus .popup-menu-item-icon {
+    opacity: 1;
+}
 
 
 /* Anki errors */
diff --git a/ext/css/material.css b/ext/css/material.css
index 2c7195cb..f9ab59bf 100644
--- a/ext/css/material.css
+++ b/ext/css/material.css
@@ -947,11 +947,11 @@ button.icon-button:active {
 }
 button.popup-menu-item {
     padding: 0.625em 1.5em;
+    flex: 1 1 auto;
     border-radius: 0;
     background-color: transparent;
     color: var(--text-color);
     border: none;
-    width: 100%;
     text-align: left;
     font-size: 1em;
     font-weight: normal;
@@ -977,12 +977,14 @@ button.popup-menu-item:disabled {
     width: calc(16em / 14);
     height: calc(16em / 14);
     background-color: var(--text-color);
-    margin-right: 0.5em;
     flex: 0 0 auto;
 }
 .popup-menu-item-icon:not([hidden]) {
     display: block;
 }
+.popup-menu-item-icon+.popup-menu-item-label {
+    margin-left: 0.5em;
+}
 :root[data-page-type=popup] .popup-menu.popup-menu-auto-size,
 .popup-menu.popup-menu-small {
     border-radius: calc(var(--menu-border-radius) * 0.75);
@@ -995,6 +997,7 @@ button.popup-menu-item:disabled {
     font-size: var(--font-size-small);
 }
 .popup-menu-item-group {
+    position: relative;
     display: flex;
     flex-flow: row nowrap;
     align-items: stretch;
diff --git a/ext/display-templates.html b/ext/display-templates.html
index 82a9b97f..3074e287 100644
--- a/ext/display-templates.html
+++ b/ext/display-templates.html
@@ -158,6 +158,9 @@
 
 <!-- Popup menu -->
 <template id="audio-button-popup-menu-template"><div class="popup-menu-container scan-disable audio-button-popup-menu" tabindex="-1" role="dialog"><div class="popup-menu popup-menu-auto-size"><div class="popup-menu-body"></div></div></div></template>
-<template id="audio-button-popup-menu-item-template"><div class="popup-menu-item-group"><button class="popup-menu-item" data-menu-action="playAudioFromSource"><div class="popup-menu-item-icon icon" data-icon="none"></div><span class="popup-menu-item-label"></span></button></div></template>
+<template id="audio-button-popup-menu-item-template"><div class="popup-menu-item-group">
+    <button class="popup-menu-item popup-menu-item-audio-button" data-menu-action="playAudioFromSource"><div class="popup-menu-item-icon icon" data-icon="none"></div><span class="popup-menu-item-label"></span></button>
+    <button class="popup-menu-item popup-menu-item-set-primary-audio-button" data-menu-action="setPrimaryAudio" title="Use as audio for Anki card"><div class="popup-menu-item-icon icon" data-icon="note-card"></div></button>
+</div></template>
 
 </body></html>
diff --git a/ext/js/display/display-audio.js b/ext/js/display/display-audio.js
index 0ccb4eef..cbc7cffc 100644
--- a/ext/js/display/display-audio.js
+++ b/ext/js/display/display-audio.js
@@ -166,6 +166,12 @@ class DisplayAudio {
         }
     }
 
+    getPrimaryCardAudio(expression, reading) {
+        const cacheEntry = this._getCacheItem(expression, reading, false);
+        const primaryCardAudio = typeof cacheEntry !== 'undefined' ? cacheEntry.primaryCardAudio : null;
+        return primaryCardAudio;
+    }
+
     // Private
 
     _onAudioPlayButtonClick(definitionIndex, expressionIndex, e) {
@@ -185,27 +191,78 @@ class DisplayAudio {
     }
 
     _onAudioPlayMenuCloseClick(definitionIndex, expressionIndex, e) {
-        const {detail: {action, item}} = e;
+        const {detail: {action, item, menu}} = e;
         switch (action) {
             case 'playAudioFromSource':
-                {
-                    const group = item.closest('.popup-menu-item-group');
-                    if (group === null) { break; }
-
-                    const {source, index} = group.dataset;
-                    let sourceDetailsMap = null;
-                    if (typeof index !== 'undefined') {
-                        const index2 = Number.parseInt(index, 10);
-                        sourceDetailsMap = new Map([
-                            [source, {start: index2, end: index2 + 1}]
-                        ]);
-                    }
-                    this.playAudio(definitionIndex, expressionIndex, [source], sourceDetailsMap);
-                }
+                this._playAudioFromSource(definitionIndex, expressionIndex, item, menu);
+                break;
+            case 'setPrimaryAudio':
+                e.preventDefault();
+                this._setPrimaryAudio(definitionIndex, expressionIndex, item, menu, true);
                 break;
         }
     }
 
+    _getCacheItem(expression, reading, create) {
+        const key = this._getExpressionReadingKey(expression, reading);
+        let cacheEntry = this._cache.get(key);
+        if (typeof cacheEntry === 'undefined' && create) {
+            cacheEntry = {
+                sourceMap: new Map(),
+                primaryCardAudio: null
+            };
+            this._cache.set(key, cacheEntry);
+        }
+        return cacheEntry;
+    }
+
+    _getMenuItemSourceInfo(item) {
+        const group = item.closest('.popup-menu-item-group');
+        if (group === null) { return null; }
+
+        let {source, index} = group.dataset;
+        if (typeof index !== 'undefined') {
+            index = Number.parseInt(index, 10);
+        }
+        const hasIndex = (Number.isFinite(index) && Math.floor(index) === index);
+        if (!hasIndex) {
+            index = 0;
+        }
+        return {source, index, hasIndex};
+    }
+
+    _playAudioFromSource(definitionIndex, expressionIndex, item, menu) {
+        const sourceInfo = this._getMenuItemSourceInfo(item);
+        if (sourceInfo === null) { return; }
+
+        const {source, index, hasIndex} = sourceInfo;
+        const sourceDetailsMap = hasIndex ? new Map([[source, {start: index, end: index + 1}]]) : null;
+
+        this._setPrimaryAudio(definitionIndex, expressionIndex, item, menu, false);
+
+        this.playAudio(definitionIndex, expressionIndex, [source], sourceDetailsMap);
+    }
+
+    _setPrimaryAudio(definitionIndex, expressionIndex, item, menu, canToggleOff) {
+        const sourceInfo = this._getMenuItemSourceInfo(item);
+        if (sourceInfo === null) { return; }
+
+        const {source, index} = sourceInfo;
+        if (!this._sourceIsDownloadable(source)) { return; }
+
+        const expressionReading = this._getExpressionAndReading(definitionIndex, expressionIndex);
+        if (expressionReading === null) { return; }
+
+        const {expression, reading} = expressionReading;
+        const cacheEntry = this._getCacheItem(expression, reading, true);
+
+        let {primaryCardAudio} = cacheEntry;
+        primaryCardAudio = (!canToggleOff || primaryCardAudio === null || primaryCardAudio.source !== source || primaryCardAudio.index !== index) ? {source, index} : null;
+        cacheEntry.primaryCardAudio = primaryCardAudio;
+
+        this._updateMenuPrimaryCardAudio(menu.bodyNode, expression, reading);
+    }
+
     _getAudioPlayButtonExpressionIndex(button) {
         const expressionNode = button.closest('.term-expression');
         if (expressionNode !== null) {
@@ -229,13 +286,7 @@ class DisplayAudio {
     }
 
     async _createExpressionAudio(sources, sourceDetailsMap, expression, reading, details) {
-        const key = this._getExpressionReadingKey(expression, reading);
-
-        let sourceMap = this._cache.get(key);
-        if (typeof sourceMap === 'undefined') {
-            sourceMap = new Map();
-            this._cache.set(key, sourceMap);
-        }
+        const {sourceMap} = this._getCacheItem(expression, reading, true);
 
         for (let i = 0, ii = sources.length; i < ii; ++i) {
             const source = sources[i];
@@ -383,10 +434,10 @@ class DisplayAudio {
     }
 
     _getPotentialAvailableAudioCount(expression, reading) {
-        const key = this._getExpressionReadingKey(expression, reading);
-        const sourceMap = this._cache.get(key);
-        if (typeof sourceMap === 'undefined') { return null; }
+        const cacheEntry = this._getCacheItem(expression, reading, false);
+        if (typeof cacheEntry === 'undefined') { return null; }
 
+        const {sourceMap} = cacheEntry;
         let count = 0;
         for (const {infoList} of sourceMap.values()) {
             if (infoList === null) { continue; }
@@ -408,6 +459,16 @@ class DisplayAudio {
         popupMenu.prepare();
     }
 
+    _sourceIsDownloadable(source) {
+        switch (source) {
+            case 'text-to-speech':
+            case 'text-to-speech-reading':
+                return false;
+            default:
+                return true;
+        }
+    }
+
     _getAudioSources(audioOptions) {
         const {sources, textToSpeechVoice, customSourceUrl} = audioOptions;
         const ttsSupported = (textToSpeechVoice.length > 0);
@@ -431,6 +492,7 @@ class DisplayAudio {
         const results = [];
         for (const [source, displayName, supported] of rawSources) {
             if (!supported) { continue; }
+            const downloadable = this._sourceIsDownloadable(source);
             let optionsIndex = sourceIndexMap.get(source);
             const isInOptions = typeof optionsIndex !== 'undefined';
             if (!isInOptions) {
@@ -441,7 +503,8 @@ class DisplayAudio {
                 displayName,
                 index: results.length,
                 optionsIndex,
-                isInOptions
+                isInOptions,
+                downloadable
             });
         }
 
@@ -461,24 +524,27 @@ class DisplayAudio {
         // Create menu
         const {displayGenerator} = this._display;
         const menuNode = displayGenerator.instantiateTemplate('audio-button-popup-menu');
-        const menuBody = menuNode.querySelector('.popup-menu-body');
+        const menuBodyNode = menuNode.querySelector('.popup-menu-body');
 
         // Set up items based on options and cache data
         let showIcons = false;
-        for (const {source, displayName, isInOptions} of sources) {
+        for (const {source, displayName, isInOptions, downloadable} of sources) {
             const entries = this._getMenuItemEntries(source, expression, reading);
             for (let i = 0, ii = entries.length; i < ii; ++i) {
                 const {valid, index, name} = entries[i];
                 const node = displayGenerator.instantiateTemplate('audio-button-popup-menu-item');
 
-                const labelNode = node.querySelector('.popup-menu-item-label');
+                const labelNode = node.querySelector('.popup-menu-item-audio-button .popup-menu-item-label');
                 let label = displayName;
                 if (ii > 1) { label = `${label} ${i + 1}`; }
                 if (typeof name === 'string' && name.length > 0) { label += `: ${name}`; }
                 labelNode.textContent = label;
 
+                const cardButton = node.querySelector('.popup-menu-item-set-primary-audio-button');
+                cardButton.hidden = !downloadable;
+
                 if (valid !== null) {
-                    const icon = node.querySelector('.popup-menu-item-icon');
+                    const icon = node.querySelector('.popup-menu-item-audio-button .popup-menu-item-icon');
                     icon.dataset.icon = valid ? 'checkmark' : 'cross';
                     showIcons = true;
                 }
@@ -488,20 +554,25 @@ class DisplayAudio {
                 }
                 node.dataset.valid = `${valid}`;
                 node.dataset.sourceInOptions = `${isInOptions}`;
+                node.dataset.downloadable = `${downloadable}`;
 
-                menuBody.appendChild(node);
+                menuBodyNode.appendChild(node);
             }
         }
         menuNode.dataset.showIcons = `${showIcons}`;
 
+        // Update primary card audio display
+        this._updateMenuPrimaryCardAudio(menuBodyNode, expression, reading);
+
         // Create popup menu
         this._menuContainer.appendChild(menuNode);
         return new PopupMenu(sourceButton, menuNode);
     }
 
     _getMenuItemEntries(source, expression, reading) {
-        const sourceMap = this._cache.get(this._getExpressionReadingKey(expression, reading));
-        if (typeof sourceMap !== 'undefined') {
+        const cacheEntry = this._getCacheItem(expression, reading, false);
+        if (typeof cacheEntry !== 'undefined') {
+            const {sourceMap} = cacheEntry;
             const sourceInfo = sourceMap.get(source);
             if (typeof sourceInfo !== 'undefined') {
                 const {infoList} = sourceInfo;
@@ -524,4 +595,25 @@ class DisplayAudio {
         }
         return [{valid: null, index: null, name: null}];
     }
+
+    _updateMenuPrimaryCardAudio(menuBodyNode, expression, reading) {
+        const primaryCardAudio = this.getPrimaryCardAudio(expression, reading);
+        const {source: primaryCardAudioSource, index: primaryCardAudioIndex} = (primaryCardAudio !== null ? primaryCardAudio : {source: null, index: -1});
+
+        const itemGroups = menuBodyNode.querySelectorAll('.popup-menu-item-group');
+        let sourceIndex = 0;
+        let sourcePre = null;
+        for (const node of itemGroups) {
+            const {source} = node.dataset;
+            if (source !== sourcePre) {
+                sourcePre = source;
+                sourceIndex = 0;
+            } else {
+                ++sourceIndex;
+            }
+
+            const isPrimaryCardAudio = (source === primaryCardAudioSource && sourceIndex === primaryCardAudioIndex);
+            node.dataset.isPrimaryCardAudio = `${isPrimaryCardAudio}`;
+        }
+    }
 }
diff --git a/ext/js/display/display.js b/ext/js/display/display.js
index 6a2a3766..35f22718 100644
--- a/ext/js/display/display.js
+++ b/ext/js/display/display.js
@@ -1452,7 +1452,7 @@ class Display extends EventDispatcher {
         let injectedMedia = null;
         if (injectMedia) {
             let errors2;
-            ({result: injectedMedia, errors: errors2} = await this._injectAnkiNoteMedia(definition, mode, options, fields));
+            ({result: injectedMedia, errors: errors2} = await this._injectAnkiNoteMedia(definition, options, fields));
             if (Array.isArray(errors)) {
                 for (const error of errors2) {
                     errors.push(deserializeError(error));
@@ -1479,20 +1479,35 @@ class Display extends EventDispatcher {
         });
     }
 
-    async _injectAnkiNoteMedia(definition, mode, options, fields) {
+    async _injectAnkiNoteMedia(definition, options, fields) {
         const {
             anki: {screenshot: {format, quality}},
             audio: {sources, customSourceUrl, customSourceType}
         } = options;
 
         const timestamp = Date.now();
+
         const definitionDetails = this._getDefinitionDetailsForNote(definition);
-        const audioDetails = (mode !== 'kanji' && this._ankiNoteBuilder.containsMarker(fields, 'audio') ? {sources, preferredAudioIndex: null, customSourceUrl, customSourceType} : null);
+
+        let audioDetails = null;
+        if (definitionDetails.type !== 'kanji' && this._ankiNoteBuilder.containsMarker(fields, 'audio')) {
+            const primaryCardAudio = this._displayAudio.getPrimaryCardAudio(definitionDetails.expression, definitionDetails.reading);
+            let preferredAudioIndex = null;
+            let sources2 = sources;
+            if (primaryCardAudio !== null) {
+                sources2 = [primaryCardAudio.source];
+                preferredAudioIndex = primaryCardAudio.index;
+            }
+            audioDetails = {sources: sources2, preferredAudioIndex, customSourceUrl, customSourceType};
+        }
+
         const screenshotDetails = (this._ankiNoteBuilder.containsMarker(fields, 'screenshot') ? {tabId: this._contentOriginTabId, frameId: this._contentOriginFrameId, format, quality} : null);
+
         const clipboardDetails = {
             image: this._ankiNoteBuilder.containsMarker(fields, 'clipboard-image'),
             text: this._ankiNoteBuilder.containsMarker(fields, 'clipboard-text')
         };
+
         return await yomichan.api.injectAnkiNoteMedia(
             timestamp,
             definitionDetails,